Protective Effect of Microporous Natural Clinoptilolite on Lead-Induced Learning and Memory Impairment in Rats
| Author | Ahmad Nikpey | en |
| Author | Hossein Kazemian | en |
| Author | Ali Safari-Varyani | en |
| Author | Marjan Rezaie | en |
| Author | Majid Sirati-Sabet | en |
| Issued Date | 2013-05-15 | en |
| Abstract | Background: Lead poisoning impairs memory and learning. Objectives: The protective effect of natural zeolite clinoptilolite on memory and learning impairment in rats exposed to lead acetate was investigated. Materials and Methods: 60 male Wistar rats in six groups treated for 2 months with diets contained different ratios of natural zeolite(i.e. 5% or 12.5%), and %0.2 lead acetate (LA) concentrations. behavioral test was evaluated by passive avoidance learning method in shuttle box at 6, 12, 24, 48 hours, and one week after the shock test. Results: digestive exposure with 0.2% lead acetate in the presence of zeolite additive had no effect on the rats’ memory performance (P < 0.05). Adding 5 and 12.5%w/w of natural zeolite to the rats’ feed improved short-term, medium-term, and long-term memory performance (P < 0.05) compared to the control group. Conclusion: observed improvement in memory function can be considered in part as the indirect effects of cation exchange or adsorption property of zeolites. | en |
| DOI | https://doi.org/10.17795/jhealthscope-10041 | en |
| Keyword | Lead Poisoning | en |
| Keyword | Zeolites | en |
| Keyword | Clinoptilolite | en |
| Keyword | Rats | en |
| Publisher | Brieflands | en |
| Title | Protective Effect of Microporous Natural Clinoptilolite on Lead-Induced Learning and Memory Impairment in Rats | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- 20043-pdf.pdf
- Size:
- 291.98 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF