Assessment of Serum Level of Elafin in Patients with Acne Vulgaris Treated with Isotretinoin
| Author | Mohammed Abu El-Hamd | en |
| Author | Sarah Nasr El-Din Mohammed Mahmoud | en |
| Author | Ahmed Sedky | en |
| Author | Soha Aboeldahab | en |
| Orcid | Mohammed Abu El-Hamd [0000-0002-0100-624X] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Background: Acne vulgaris (AV) is a chronic inflammatory disease affecting the pilosebaceous follicle. Acne vulgaris is a prevalent disease that affects about 85% of adolescents. Acne vulgaris develops due to complex and different etiologies. Objectives: This study aimed to compare serum elafin levels of moderate and severe AV patients versus healthy controls and to assess their levels before and after treatment with systemic isotretinoin. Methods: This case-control study involved 30 patients who were clinically diagnosed with moderate and severe AV, treated with isotretinoin, and 30 age- and sex-matched healthy subjects as controls. Patients were subjected to full general and cutaneous assessments. Estimation of serum levels of elafin was performed using the enzyme-linked immunosorbent assay (ELISA) technique in controls and patients before and after isotretinoin treatment. Results: There were statistically significantly higher serum elafin levels in controls than in patients (P = 0.001). Of patients with AV, there was a statistically significant reduction of serum elafin levels after isotretinoin therapy (P < 0.05). Serum elafin had an excellent predictive power for AV. Conclusions: In AV patients, assessment of serum elafin represents a useful tool for monitoring disease activity, severity, and evaluating the response to isotretinoin therapy. | en |
| DOI | https://doi.org/10.5812/jssc-168354 | en |
| Keyword | Acne Vulgaris | en |
| Keyword | Isotretinoin | en |
| Keyword | Serum Elafin | en |
| Publisher | Brieflands | en |
| Title | Assessment of Serum Level of Elafin in Patients with Acne Vulgaris Treated with Isotretinoin | en |
| Type | Research Article | en |
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