Comparison of the Therapeutic Effects of Oral Fluoxetine and Topical Clobetasol with Topical Clobetasol and Placebo in Vitiligo Patients: A Triple Blinded Placebo Control Clinical Trial
| Author | Nazila Poostiyan | en |
| Author | Zabihollah Shahmoradi | en |
| Author | Mohammad Shoushtarizadeh | en |
| Author | Mohammadreza Pordeli | en |
| Author | Rasoul Montazeri | en |
| Issued Date | 2025-09-30 | en |
| Abstract | Background: Assess whether adding fluoxetine (20 mg daily) to topical clobetasol 0.05% is more effective than clobetasol with placebo for vitiligo. Methods: Triple-blind randomized clinical trial (CRT) in Isfahan, Iran between 2022 and 2023. Forty-one patients were randomized to: Fluoxetine+clobetasol and Placebo+clobetasol. Lesions were photographed at baseline and after 3 months. Two blinded dermatologists categorized improvement (mild, moderate, good, excellent) based on lesion size and perifollicular pigmentation. Patient satisfaction (VAS) and side effects were recorded. Results: Forty-one patients, 91 lesions (19 in the fluoxetine group, 22 in the control). Significant baseline differences: More males and older age in the fluoxetine group. No difference in lesion improvement between groups (P = 0.879). More adverse effects with fluoxetine (P = 0.006); satisfaction was similar (P = 0.310). After adjusting for age/gender, no significant differences were found. Conclusions: Adding fluoxetine to topical clobetasol did not improve vitiligo outcomes compared with clobetasol alone. | en |
| DOI | https://doi.org/10.5812/jssc-163664 | en |
| URI | https://brieflands.com/journals/jssc/articles/163664 | en |
| Keyword | Vitiligo | en |
| Keyword | Fluoxetine | en |
| Keyword | 5-HT1A Receptor | en |
| Keyword | Melanogenesis | en |
| Publisher | Brieflands | en |
| Title | Comparison of the Therapeutic Effects of Oral Fluoxetine and Topical Clobetasol with Topical Clobetasol and Placebo in Vitiligo Patients: A Triple Blinded Placebo Control Clinical Trial | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- jssc-12-3-163664-publish-pdf.pdf
- Size:
- 204.9 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF