Design, Synthesis and Biological Evaluation of 1,3-Diphenyl-3-(phenylthio)propan-1-ones as New Cytotoxic Agents
| Author | Maryam Bayanati | en |
| Author | Soraya Shahhosseini | en |
| Author | Farshad. H. Shirazi | en |
| Author | Golrokh Farnam | en |
| Author | Afshin Zarghi | en |
| Issued Date | 2021-10-31 | en |
| Abstract | Cancers in terms of morbidity and mortality are one of the major universal issues. New compounds of anticancer agents based on β-aryl-β-mercapto ketones scaffold possessing piperidinylethoxy or morpholinylethoxy groups were synthesized and evaluated as cytotoxic agents. Cytotoxic effects of synthesized compounds were measured against MCF-7, human ER-positive breast cancer cell lines, using MTT assay. The results indicated that all compounds had high cytotoxic activity on MCF-7 cancerous cells, even more than the reference drug Tamoxifen. Among them, compounds 3-(4-(2-morpholinoethoxy)phenyl)-1-phenyl-3-(phenylthio)propan-1-one (4a) and 1-(4-methoxyphenyl)-3-(3-(2-morpholinoethoxy)phenyl)-3-(phenylthio)propan-1-one (4h) had no significant cytotoxic effects on normal cells compared to Tamoxifen. Our results also indicated that adding tertiary amine basic side chain, found in Tamoxifen drug, to 1,3-diphenyl-3-(phenylthio)propan-1-ones improves the cytotoxic effects of these compounds on breast cancer cells. | en |
| DOI | https://doi.org/10.22037/ijpr.2021.114865.15076 | en |
| Keyword | Synthesis | en |
| Keyword | 1 | en |
| Keyword | 3-Diphenyl-3-(phenylthio)propan-1-one | en |
| Keyword | Docking study | en |
| Keyword | Cytotoxic effect | en |
| Keyword | MTT | en |
| Keyword | MCF-7 | en |
| Publisher | Brieflands | en |
| Title | Design, Synthesis and Biological Evaluation of 1,3-Diphenyl-3-(phenylthio)propan-1-ones as New Cytotoxic Agents | en |
| Type | Original Article | en |
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