Human Calprotectin, a Potent Anticancer with Minimal Side Effect

Abstract

Background: Chemotherapy by using agents such as etoposide is a common way for inhibition of tumors. This treatment is accompanied by many undesirable side effects. Calprotectin is an abundant protein in the neutrophil cytosol, it has growth-inhibitory and apoptosis-inducing activities against various cell types such as tumor cells. In this study to introduce calprotectin as a suitable substitute anticancer, its growth inhibitory effect on human gastric adenocarcinoma cell line (AGS) and human foreskin fibroblast cells (HFFF) is compared to etoposide effect on these two cell lines.