Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents
| Author | Talavara Venkatesh | en |
| Author | Yadav Dasharathrao Bodke | en |
| Author | Muthipeedika Nibin Joy | en |
| Author | Bhadrapura Lakkappa Dhananjaya | en |
| Author | Sivaramakrishnan Venkataraman | en |
| Issued Date | 2018-01-31 | en |
| Abstract | In this investigation, the synthesis of 2-substituted pyrimidines by the reaction of benzofuran chalcones (3a-d) with urea, thiourea and guanidine hydrochloride was reported. The structures of title compounds (4a-d), (5a-d) and (6a-d) were established on the basis of analytical and spectral data. The synthesized compounds were screened for antimicrobial activity and molecular docking studies. Some of the compounds displayed excellent antimicrobial activity. The molecular docking analysis revealed that compounds 5a and 5c with the lowest binding energy in comparison to others suggesting its potential as best inhibitor of GluN-6-P. Consequently, it is confirmed from the above analysis that the compounds 5a and 5c might serve as a useful backbone scaffold for rational design, adaptation and investigation of more active analogs as potential broad spectrum antimicrobial agents. | en |
| DOI | https://doi.org/10.22037/ijpr.2018.2181 | en |
| URI | https://brieflands.com/journals/ijpr/articles/124742 | en |
| Keyword | Benzofuran chalcones | en |
| Keyword | Hydroxy pyrimidines | en |
| Keyword | Thiopyrimidines | en |
| Keyword | Amino pyrimidines | en |
| Keyword | Antimicrobial activity | en |
| Keyword | Molecular docking studies | en |
| Publisher | Brieflands | en |
| Title | Synthesis of Some Benzofuran Derivatives Containing Pyrimidine Moiety as Potent Antimicrobial Agents | en |
| Type | Research Article | en |
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