Effect of Charge on Separation of Liposomes upon Stagnation

Abstract

Liposomes are used widely as drug delivery systems in different forms including nanosuspensions, osmotic pumps, infusion pumps, and IV injections. Some of these systems (e.g. infusion or osmotic pumps) might stay stagnant for a long time during or before administration, and therefore, might face phase separation. In spite of these, there are no data available about the behavior of liposomal systems upon stagnation in such drug delivery systems. As a part of a series of investigations on convective flow and stagnation of liposomes, the current work represents the effects of charge on liposomes separation upon stagnation.