The Association of Serum Osteopontin Levels with Insulin Resistance in Obese, Dyslipidemic Children
| Author | Sahin Hamilcıkan | en |
| Author | Meltem Erol | en |
| Author | Ozlem Bostan Gayret | en |
| Author | Ovgu Buke | en |
| Author | Emrah Can | en |
| Orcid | Meltem Erol [0000-0002-7672-1854] | en |
| Issued Date | 2017-02-28 | en |
| Abstract | Objectives: To assess serum osteopontin (OPN) concentrations and to evaluate the correlation between OPN levels and insulin resistance (IR) in obese dyslipidemic children. Methods: The study featured 107 obese children with ages ranging between 3 - 17 years. Anthropometrical measurements and biochemical analyses were performed and serum OPN samples were obtained. IR was defined using the homeostasis model assessment-insulin resistance (HOMA-IR) protocol. Results: Of the 107 obese children that were recruited for the study, 63 were girls (58.9%) and 44 were boys (58.9%), with a mean age of 11.18 ± 3.41 years. Of them, 21 (19.6%) were diagnosed with dyslipidemia. No significant differences in age and gender were identified between the dyslipidemic and non-dyslipidemic groups. The mean body mass index (BMI), fasting blood glucose, insulin, and alanine transaminase levels were similar in both groups (P = 0.74). The average total cholesterol (TC), low-density lipoprotein cholesterol (LDL), and triglyceride (TG) levels were higher, while the high-density lipoprotein (HDL) and cholesterol levels were lower in the dyslipidemic group. Amongst the children with dyslipidemia, 28 (84.84%) had IR. The mean OPN levels in the dyslipidemic group were not found to be higher than the non-dyslipidemic group (46.94 ± 25.64 vs 48.92 ± 24.45; P = 0.70). Multivariate regression analysis confirmed that increased HOMA-IR levels (P = 0.01) are an important risk factor for dyslipidemia. Conclusions: While serum OPN levels were found to be related to IR in obese children, OPN levels were not associated with dyslipidemia. | en |
| DOI | https://doi.org/10.5812/ijp.7483 | en |
| Keyword | Osteopontin | en |
| Keyword | Obesity | en |
| Keyword | Dyslipidemia | en |
| Keyword | Insulin Resistance | en |
| Publisher | Brieflands | en |
| Title | The Association of Serum Osteopontin Levels with Insulin Resistance in Obese, Dyslipidemic Children | en |
| Type | Research Article | en |
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