Negative Association of Plasma Levels of Vitamin D and miR-378 With Viral Load in Patients With Chronic Hepatitis B Infection
| Author | Ashraf Mohamadkhani | en |
| Author | Faegh Bastani | en |
| Author | Samaneh Khorrami | en |
| Author | Reza Ghanbari | en |
| Author | Sareh Eghtesad | en |
| Author | Maryam Sharafkhah | en |
| Author | Ghodratollah Montazeri | en |
| Author | Hossein Poustchi | en |
| Orcid | Hossein Poustchi [0000-0003-4566-3628] | en |
| Issued Date | 2015-06-01 | en |
| Abstract | Background: Chronic Hepatitis B (CHB) is accompanied by inflammation of liver because of infection with Hepatitis B Virus (HBV). Previous studies revealed an inverse association between vitamin D and HBV DNA levels. Objectives: The current study aimed to investigate the levels of 25 (OH) D3 (the steady form of vitamin D), miR-378 and HBV DNA in the patients with CHB. Patients and Methods: One hundred and seventy three patients with HBeAg negative CHB were recruited for the study. Plasma levels of HBVDNA and 25 (OH) D3 were quantified. The expression level of miR-378 in plasma was measured by a relative quantitative Real Time Polymerase Chain Reaction (qRT-PCR) assay. Results: In the pathway regression analysis, the plasma level of 25 (OH) D3 showed a significant inverse correlation with plasma levels of HBV DNA (-0.198, P = 0.008) and direct correlation with miR-378 (0.188, P = 0.013). Similarly plasma level of miR-378 had inverse association with HBV DNA level (-0.177, P = 0.020). Conclusions: These results suggest that vitamin D could involve in a miRNA- mediated regulatory pathway in control of HBV replication. Further studies are recommended to understand the effects of miR-378 and anti-infective action of vitamin D on Hepatitis B Virus. | en |
| DOI | https://doi.org/10.5812/hepatmon.28315v2 | en |
| URI | https://brieflands.com/journals/hepatmon/articles/15492 | en |
| Keyword | Chronic Hepatitis B | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Vitamin D | en |
| Keyword | miR-378 | en |
| Publisher | Brieflands | en |
| Title | Negative Association of Plasma Levels of Vitamin D and miR-378 With Viral Load in Patients With Chronic Hepatitis B Infection | en |
| Type | Research Article | en |
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