Effect of Swimming Exercise to Cardiac PGC-1 α and HIF-1 α Gene Expression in Mice
| Author | Nova Sylviana | en |
| Author | Niswan Helja | en |
| Author | Hadaral Hudanul Qolbi | en |
| Author | Hanna Goenawan | en |
| Author | Ronny Lesmana | en |
| Author | Mas Rizky A A Syamsunarno | en |
| Author | Hasrayati Agustina | en |
| Author | Badai Batara Tiksnadi | en |
| Author | Imam Megantara | en |
| Author | Vita Murniati Tarawan | en |
| Author | Setiawan Setiawan | en |
| Author | Bethy Hernowo | en |
| Author | Unang Supratman | en |
| Author | Ambrosius Purba | en |
| Issued Date | 2018-12-31 | en |
| Abstract | Background: Hypoxia caused by exercise condition may alter PGC-1α and HIF-1α expression in cardiac cells. Both factors are transcriptional factors which play a role in conserving energy during metabolic process. However, there is less information about the effects of long term moderate intensity exercise such as swimming on PGC-1α and HIF-1α expression in cardiac cells. Objectives: Aim of this study is to observe the effect of force swimming exercise on the expression PGC-1α and HIF-1α gene expression in cardiac muscle of mice. Methods: Male BALBc mice were divided into two groups (n = 10): control (C) and swimming (ST). ST group was subjected to moderate intensity swimming for 4 weeks, 30 minutes/day for 5 days. Hearts of animal models were preserved for cardiac morphology study using HE staining, PGC-1α and HIF-1α mRNA expression study. Results: We observed that cardiac PGC-1α expression in ST was significantly increased 1.5 fold compared with control group (0.64 vs 0.44; CI = 95%, -0.378 - 0.019; P = 0.035), but expression of HIF-1α was significantly decreased 0.4 times lower than control group (0.35 vs 0.52; CI = 95%, 0.27 - 0.31; P = 0,025). Conclusions: Taken together, ST group increased the expression of PGC-1α but decreased the expression of HIF-1α in mice cardiac muscle in response to chronic hypoxia condition. | en |
| DOI | https://doi.org/10.5812/asjsm.65079 | en |
| Keyword | Cardiac | en |
| Keyword | Swimming | en |
| Keyword | HIF-1α | en |
| Keyword | PGC-1α | en |
| Keyword | Hypoxia | en |
| Keyword | Moderate Intensity | en |
| Publisher | Brieflands | en |
| Title | Effect of Swimming Exercise to Cardiac PGC-1 α and HIF-1 α Gene Expression in Mice | en |
| Type | Research Article | en |