The Effect of Ubiquitin Like Protein-Proteasome System on the Drug Resistance of Isoniazid Mono-Resistant <i>Mycobacterium tuberculosis</i>

Abstract

Tuberculosis (TB) is one of the most widespread and lethal infectious diseases worldwide. The emergence of drug-resistant TB has hampered effective TB treatment and control. Prokaryotic ubiquitin-like Protein-Proteasome System (PPS) contributes to the survival of Mycobacterium tuberculosis in the host. However, whether PPS effects drug resistance of isoniazid mono-resistant Mycobacterium tuberculosis (INH-MTB) is still unknown.