Synthesis and Antimicrobial Evaluation of New (4-Oxo-thiazolidinyl)quinazolin-4(3H)ones of 2-[(2,6-Dichlorophenyl)amino]phenylacetic acid
| Author | Navin B.Patel | en |
| Author | Virendra N.Patel | en |
| Issued Date | 2007-10-31 | en |
| Abstract | Synthesis of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[4-(2-substitutedphenyl-4-oxo-thiazolidinyl)aryl]-6-bromo quinazolin-4(3H)ones VIa-j have been achieved from the starting material 2-[(2,6-dichlorophenyl)amino] phenylacetic acid I to benzoxazine III, Further reaction with p-phenylindiamine and substituted aromatic aldehyde gave 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-(4-aminoaryl)-6-bromo quinazolin-4(3H)-ones IV and 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[4-(2-substituted arylidene)aryl]-6-bromo quinazolin-4(3H)ones Va-j respectively. Va-j on cyclization with thioglycolic acid gave VIa-j. All the synthesized compounds have been characterized on the basis of elemental analysis, IR and 1H-NMR spectral data. They were screened for antibacterial and antifungal activity at two concentrations and compared with the standard drugs penicillin-G, ampicillin, and amoxicillin. The compounds containing 4-OCH3 and 3, 4, 5-(OCH3)3 showed good activity, compared with the standard drugs. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.729 | en |
| Keyword | Antifungal | en |
| Keyword | Antibacterial | en |
| Keyword | P-Phenylenediamine | en |
| Keyword | Thiazolidinone | en |
| Keyword | Quinazolinone | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Antimicrobial Evaluation of New (4-Oxo-thiazolidinyl)quinazolin-4(3H)ones of 2-[(2,6-Dichlorophenyl)amino]phenylacetic acid | en |
| Type | Research Article | en |
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