Relationship Between HBV Genotypes B, C and Follicular Helper T Cells in Patients with Chronic Hepatitis B and its Significance
| Author | Gu Xibing | en |
| Author | Yang Xiaojuan | en |
| Author | Wang Juanhua | en |
| Author | Hua Zhong | en |
| Issued Date | 2013-01-20 | en |
| Abstract | Background: Clinical observations have shown that patients infected with chronic hepatitis B virus (HBV) genotype C versus genotype B had a higher load of the virus, more serious illness, and poorer responses to antiviral therapy and prognosis. However, the disparity between the two has not been clarified. Objectives: To explore possible relationship between HBV genotypes B and C and peripheral blood follicular helper T cells (Tfh) and its significance in treating chronic hepatitis B (CHB) patients. Patients and Methods: One hundred and fifty CHB patients were enrolled into this study, including 70 cases infected with HBV genotype C and 79 cases with genotype B. One patient had suffered from both genotypes B and C. The levels of Tfh, also known as interleukin-21 (IL-21), HBV specific cytotoxic T lymphocytes (CTL), HBV DNA and alanine transaminase (ALT) were evaluated and compared in patients infected with genotype B and C. Results: Levels of Tfh, IL-21 and HBV specific CTL of patients infected with HBV genotype C were significantly lower than those of patients infected with HBV genotype B, P < 0.01. Levels of HBV DNA and ALT of patients infected with genotype C were significantly higher than those of the patients infected with HBV genotype B, P < 0.01. Conclusions: Compared with chronic hepatitis B (CHB) patients infected with genotype B, higher levels of serum HBV DNA, ALT and TBil of patients infected with HBV genotype C may be related to their lower level of peripheral blood Tfh, which may result in lower IL-21, and it may result in lower HBV specific CTL. | en |
| DOI | https://doi.org/10.5812/hepatmon.6221 | en |
| Keyword | Hepatitis B Virus | en |
| Keyword | Genotype | en |
| Keyword | T-Lymphocytes | en |
| Keyword | Helper-Inducer | en |
| Keyword | Receptors | en |
| Keyword | Interleukin-21 | en |
| Keyword | Cytotoxic | en |
| Publisher | Brieflands | en |
| Title | Relationship Between HBV Genotypes B, C and Follicular Helper T Cells in Patients with Chronic Hepatitis B and its Significance | en |
| Type | Research Article | en |
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