Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
| Author | Ramin Miri | en |
| Author | Katayoun Javidnia | en |
| Author | Zahra Amirghofran | en |
| Author | Seyyed Hossein Salimi | en |
| Author | Zahra Sabetghadam | en |
| Author | Savis Meili | en |
| Author | Ahmad Reza Mehdipour | en |
| Issued Date | 2011-07-31 | en |
| Abstract | The 1,4-dihydropyridine (DHP) derivatives are a known class of calcium channel blockers. Some derivatives of DHP showed significant cytotoxicity. It was shown that this effect may not be the result of interaction with Ca2+ channels. In this study, we performed an investigation about the intrinsic cytotoxicity of some derivatives of DHP containing nitroimidazole moiety on their C4 position on four different cancer cell lines (Raji, K562, Fen and HeLa). The result showed that these compounds had moderate-good cytotoxic activity. In addition, QSAR model shows the importance of N atom in cytotoxicity; Ca2+ channels. | en |
| DOI | https://doi.org/10.22037/ijpr.2011.991 | en |
| Keyword | 1,4-Dihydropyridines | en |
| Keyword | Cytotoxicity | en |
| Keyword | MTT assay | en |
| Keyword | Nitroimidazole | en |
| Publisher | Brieflands | en |
| Title | Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety | en |
| Type | Original Article | en |
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