Synthesis, Structural Characterization, and Cytotoxic Activity of New Benzo[d]imidazo[2,1-b]thiazole Derivatives Against MCF-7 Breast Cancer Cells
| Author | Nahid Ahmadi | en |
| Author | Soraya Shahhosseini | en |
| Author | Farshad H Shirazi | en |
| Author | Golrokh Farnam | en |
| Author | Afshin Zarghi | en |
| Orcid | Farshad H Shirazi [0000-0003-1356-385X] | en |
| Orcid | Afshin Zarghi [0000-0002-6470-7895] | en |
| Issued Date | 2022-12-31 | en |
| Abstract | Breast cancer is an invasive disease with a high prevalence among females. Despite various treatments, studies are still ongoing to find an effective treatment for this disease. This study aimed to synthesize a new series of diaryl benzo[d]imidazo[2,1-b]thiazole compounds containing aminoethoxy side chain and in vitro investigate their cytotoxicity on a human breast cancer cell line (MCF-7). Twelve derivatives (6a-6l) were synthesized from this scaffold, the structures of which were spectroscopically confirmed. The cytotoxic effects of the derivatives on the MCF-7 cell line were also assessed using the MTT assay. All these compounds showed a good inhibitory effect on the MCF-7 cell line, compared to that of tamoxifen. Compounds (6i) and (6j) showed higher cytotoxicity with relevant inhibitory effects of 81% and 73%, respectively. | en |
| DOI | https://doi.org/10.5812/ijpr-127041 | en |
| Keyword | Synthesis | en |
| Keyword | Breast Cancer | en |
| Keyword | Benzo[d]imidazo[2,1-b]thiazoles | en |
| Keyword | Docking | en |
| Keyword | Cytotoxicity | en |
| Publisher | Brieflands | en |
| Title | Synthesis, Structural Characterization, and Cytotoxic Activity of New Benzo[d]imidazo[2,1-b]thiazole Derivatives Against MCF-7 Breast Cancer Cells | en |
| Type | Research Article | en |