<i>Bacillus coagulans</i> T4 and <i>Lactobacillus paracasei</i> TD3 Ameliorate Skeletal Muscle Oxidative Stress and Inflammation in High-Fat Diet-Fed C57BL/6J Mice
| Author | Masoumeh Shams | en |
| Author | Fataneh Esmaeili | en |
| Author | Samira Sadeghi | en |
| Author | Mahsa Shanaki-Bavarsad | en |
| Author | Shadi Sadat Seyyed Ebrahimi | en |
| Author | Seyyed Mohammad Reza Hashemnia | en |
| Author | Maryam Tajabadi-Ebrahimi | en |
| Author | Solaleh Emamgholipour | en |
| Author | Mehrnoosh Shanaki | en |
| Orcid | Maryam Tajabadi-Ebrahimi [0000-0003-2780-3447] | en |
| Issued Date | 2023-12-31 | en |
| Abstract | Background: This study aims to investigate the effects of Bacillus coagulans T4 and Lactobacillus paracasei TD3 probiotics on skeletal muscle inflammation and oxidative stress in C57BL/6J mice fed a high-fat diet (HFD). Methods: Probiotics B. coagulans T4, and L. paracasei TD3 were administered to male C57BL/6J mice fed with HFD. The gene expression of macrophage infiltration markers, inflammatory cytokines, and oxidative stress indicators in the muscle tissue was investigated. Results: Treatment with B. coagulans T4 and L. paracasei TD3 reduced macrophage infiltration, accompanied by a decrease in the expression of monocyte chemoattractant protein-1 (MCP-1) and an increase in the expression of interleukin (IL)-10. On the other hand, L. paracasei TD3 decreased malondialdehyde (MDA) while B. coagulans T4 decreased carbonyl and increased catalase activity. Conclusions: Treatment with probiotics B. coagulans T4 and L. paracasei TD3 partially ameliorated obesity-induced skeletal muscle inflammation in HFD-fed mice. | en |
| DOI | https://doi.org/10.5812/ijpr-135249 | en |
| Keyword | High-Fat Diet | en |
| Keyword | Skeletal Muscle | en |
| Keyword | Inflammation | en |
| Keyword | Oxidative Stress | en |
| Keyword | Probiotic | en |
| Publisher | Brieflands | en |
| Title | <i>Bacillus coagulans</i> T4 and <i>Lactobacillus paracasei</i> TD3 Ameliorate Skeletal Muscle Oxidative Stress and Inflammation in High-Fat Diet-Fed C57BL/6J Mice | en |
| Type | Research Article | en |