Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial
| Author | Abbas Javadzadeh Bolouri | en |
| Author | Atessa Pakfetrat | en |
| Author | Arghavan Tonkaboni | en |
| Author | Seyed Amir Aledavood | en |
| Author | Mohsen Fathi Najafi | en |
| Author | Zahra Delavarian | en |
| Author | Mohammad Taghi Shakeri | en |
| Author | Azade Mohtashami | en |
| Issued Date | 2015-10-28 | en |
| Abstract | Background:: Mucositis is one of the acute complications of radiotherapy which can ulcerate oral mucosa and cause severe pain and discomfort which can affect oral normal function. Propolis is a natural source of flavenoid which has antiulcer, antibacterial, antifungal, healing and anti-inflammatory effects. Using such an affordable compound without any bad smell or taste that has reasonable price can help the radiotherapy undergoing patients. Objectives:: Our goal is assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis in patients with head and neck cancer. Patients and Methods:: In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). we use NIC-CTC scale for determining mucositis grading. Results:: We use T-test, Man-Whitney, Chi-square, and Friedman as analyzing tests. Case group had significantly (P < 0.05) lower grade of mucositis in all of the follow-ups, but xerostomia is not significantly different in two groups (P > 0.05). Conclusions:: This is a pilot study which shows water based extract of propolis efficiently prevents and heals radiotherapy induced mucositis. | en |
| DOI | https://doi.org/10.17795/ijcp-4019 | en |
| Keyword | Cancer | en |
| Keyword | Mouthwashes | en |
| Keyword | Mucositis | en |
| Keyword | Propolis | en |
| Keyword | Radiotherapy | en |
| Publisher | Brieflands | en |
| Title | Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial | en |
| Type | Research Article | en |
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