Solid SMEDDS: An Approach for Dissolution Rate Enhancement Using Telmisartan as Model Drug
| Author | Ashish Pawar | en |
| Author | Yogesh S Harak | en |
| Author | Santosh R Tambe | en |
| Author | Swati Talele | en |
| Author | Deepak D Sonawane | en |
| Author | Deelip V Derle | en |
| Issued Date | 2021-12-31 | en |
| Abstract | Bioavailability improvement of poorly water-soluble drugs is a challenging task for many of the drug candidates. In recent years, an area that is ahead in popularity for different formulation expertise is the use of lipid-based careers to formulate self-emulsifying drug delivery systems (SEDDS) for enhancing the oral bioavailability of lipophilic drugs. The self-microemulsifying drug delivery systems (SMEDDS) are thermodynamically stable and isotropic solutions containing an oil, surfactant, co-surfactant (CoS; or solubilizer), and mixtures of drug which forms oil-in-water microemulsions when incorporated in water and stirred. Different techniques are available to convert liquid–self-microemulsifying drug delivery systems (L-SMEDDS) to solid among which an adsorption technique is economical and very simple. The solid– self-microemulsifying drug delivery systems (S-SMEDDS) of telmisartan (TEL) was developed in the present study which is a poorly water-soluble drug. Different formulations of L-SMEDDS were developed using Capmul PG 8 as oil, Cremophor RH 40 as a surfactant, and Transcutol P as a CoS and were later transformed to S-SMEDDS. The formulations were assessed for dilution study by visual observation, differential scanning calorimetry, analysis of solid S-SMEDDS morphologically, in vitro dissolution test, zeta potential measurement, etc. Significantly higher drug release was observed from S-SMEDDS as compared to plain TEL. Hence, it can be concluded that the adsorption technique is a promising approach for the formulation of S-SMEDDS with improved dissolution rate and concomitantly bioavailability. | en |
| DOI | https://doi.org/10.4103/jrptps.JRPTPS_6_20 | en |
| Keyword | SMEDDS | en |
| Keyword | solubility | en |
| Keyword | telmisartan | en |
| Keyword | zeta potential | en |
| Publisher | Brieflands | en |
| Title | Solid SMEDDS: An Approach for Dissolution Rate Enhancement Using Telmisartan as Model Drug | en |
| Type | Research Article | en |