Effects of Pentoxifylline on Non-Alcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial in Iran
| Author | Nadieh Baniasadi | en |
| Author | Faranak Salajegheh | en |
| Author | Abbas Pardakhty | en |
| Author | Seyed Mehdi Seyedmirzaee | en |
| Author | Mohammad Mahdi Hayatbakhsh | en |
| Author | Amin Reza Nikpoor | en |
| Author | Mojgan Mohammadi | en |
| Issued Date | 2015-11-30 | en |
| Abstract | Background:: Non-alcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease. Several studies suggest that pentoxifylline (PTX) can improve the disease outcome. Objectives:: We aimed to compare the effect of pentoxifylline with placebo on liver aminotransferases and cytokines, including interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin 8 (IL-8) in patients with NASH. Patients and Methods:: Thirty patients with NASH were included in the study, based on ultrasonography and 1.5-fold mean change from baseline serum levels of liver aminotransferases. Patients with NASH were randomized to receive 1200 mg PTX (the intervention group) or placebo (the placebo group) for 6 months. The serum levels of liver aminotransferases and cytokines were compared between the intervention and placebo groups, at various time points. Results:: The serum levels of liver aminotransferases were significantly reduced at 3 months and at 6 months, compared with baseline, in both groups. The serum levels of IL-6 were significantly decreased, in both groups, only at 6 months, compared with baseline. Compared to the placebo group, the serum level of TNF-α was significantly decreased in the intervention group, at 6 months. The serum level of IL-8 was increased, in both groups, after 6 months, without reaching clinical significance. There was no significant difference in serum levels of liver aminotransferases and cytokines, between intervention and placebo groups. Conclusions:: Decreases in the serum levels of liver aminotransferases and cytokines, in both groups, are related to low-calorie diets and exercise, rather than PTX. | en |
| DOI | https://doi.org/10.5812/hepatmon.33462 | en |
| Keyword | Non-Alcoholic Fatty Liver Disease | en |
| Keyword | Cytokines | en |
| Keyword | Pentoxifylline | en |
| Keyword | Clinical Trial | en |
| Publisher | Brieflands | en |
| Title | Effects of Pentoxifylline on Non-Alcoholic Steatohepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial in Iran | en |
| Type | Research Article | en |
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