Effect of <i>Pimpinellatirupatiensison</i> Oxidative Enzymes in STZ-induced Diabetic Rat Kidney
| Author | Saddala RajeswaraReddy | en |
| Author | Thopireddy Lavany | en |
| Author | Ganapathi Narasimhulu | en |
| Author | Kesireddy SathyaveluReddy | en |
| Issued Date | 2012-01-31 | en |
| Abstract | The present study was aimed to evaluate the therapeutic potential of Pimpinellatirupatiensis(Pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. Diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes Succinate dehydrogenase (SDH), Malate dehydrogenase (MDH), Glutamate dehydrogenase (GDH) and isocitrate dehydrogenase (ICDH). Lactate dehydrogenase (LDH) activity was significantly (p < 0.01) increased in diabetic rats. The daily oral treatment of Pimpinellatirupatiensisethyl alcohol extract (750 mg/kg body weight/day) to diabetic rats for 30 days reversed the above changes in a significant (p < 0.01) manner. From our observations, we conclude that administration of Pt altered the activities of oxidative enzymes, thereby suggesting its role in mitochondrial energy production. The obtained results were compared with Glibenclamide, a standard anti diabetic drug. Thus, the modulatory effects of Pt on altering these enzymes activities afford a promise for widespread use for treatment of diabetes in the future. | en |
| DOI | https://doi.org/10.22037/ijpr.2012.1083 | en |
| Keyword | <i>Pimpinellatirupatiensis</i> | en |
| Keyword | Diabetes | en |
| Keyword | Mitochondrial enzymes | en |
| Keyword | Oxidative stress | en |
| Publisher | Brieflands | en |
| Title | Effect of <i>Pimpinellatirupatiensison</i> Oxidative Enzymes in STZ-induced Diabetic Rat Kidney | en |
| Type | Original Article | en |
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