In Vitro Antioxidant Activity and Total Phenolic Content of Root Extracts from Phragmanthera glaucocarpa (Peyr.) Balle
| Author | Nelson António Freitas Fernandes | en |
| Author | Laura Isabel Nave Canelo | en |
| Author | Rosalina da Conceição dos Santos Mata | en |
| Author | Dina Isabel Malheiros Dinis de Mendonça | en |
| Author | António José Geraldes de Mendonça | en |
| Issued Date | 2018-12-01 | en |
| Abstract | Background: Africa has a rich diversity of plant species, which can be considered important sources of new chemical compounds that can be used in the development of novel therapeutic drugs. Objectives: The present study aimed at investigating the antioxidant activity and total phenolic content of extracts obtained from the roots of Phragmanthera glaucocarpa (Peyr.) Balle, a plant used in Angola folk medicine. Methods: The prepared extracts were tested for their antioxidant activity using ABTS (2,2’-azinobis-(3-ethyl-benzothiazoline-6-sulfonic acid), DPPH (1’,1’-diphenyl-2-picrylhydrazyl), and peroxide value methods. Total phenolics were evaluated by the Folin-Ciocalteu method. Results: For ABTS, the best EC50 result was obtained with the ethyl acetate fraction (1.06 ± 0.30 mg/mL). For the DPPH method, the methanol extract and aqueous fraction presented the best EC50 results, 0.10 ± 0.01 mg/mL and 0.10 ± 0.00 mg/mL, respectively. The ethyl acetate fraction had the highest phenolic content (280.42 ± 0.15 mg G.A.E. /g of dry extract). The best result for the peroxide reduction value on the eighth day of sunflower oil oxidation was obtained for the aqueous fraction, with 131.40 ± 1.05 meq O2/g of lipid sample. Conclusions: The results of the present study demonstrate that the roots of the medicinal plant Phragmanthera glaucocarpa (Peyr.) Balle represent a promising source of natural phenolic compounds with antioxidant activity. | en |
| DOI | https://doi.org/10.5812/jjnpp.62238 | en |
| URI | https://brieflands.com/journals/jjnpp/articles/62238 | en |
| Keyword | Phenolic Compounds | en |
| Keyword | DPPH | en |
| Keyword | ABTS | en |
| Keyword | Peroxide Value | en |
| Keyword | Folin-Ciocalteu | en |
| Keyword | <i>Phragmanthera glaucocarpa</i> | en |
| Publisher | Brieflands | en |
| Title | <i>In Vitro</i> Antioxidant Activity and Total Phenolic Content of Root Extracts from <i>Phragmanthera glaucocarpa</i> (Peyr.) Balle | en |
| Type | Research Article | en |
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