Effect of Ethyl Acetate Extract of <i>Ferula asafoetida</i> Oleo-Gum Resin on the Glucose Level and Lipid Profile in Streptozotocin-Induced Diabetic Rats
| Author | Sara Rafiee | en |
| Author | Mohammad-Shafi Mojadadi | en |
| Author | Mehdi Molavi | en |
| Author | Samad Nazemi | en |
| Orcid | Mohammad-Shafi Mojadadi [0000-0002-8013-2059] | en |
| Orcid | Samad Nazemi [0000-0002-5081-6273] | en |
| Issued Date | 2019-06-11 | en |
| Abstract | Background: The potential antidiabetic effects of medicinal plants are investigated since long ago by researchers in medicine. Ferula asafoetida, as a medicinal herb, is traditionally used for the treatment of asthma, epilepsy, stomach pain, bloating, and diabetes. Objectives: The current study aimed at investigating the effect of ethyl acetate extract of F. asafoetida on the glucose level and lipid profile in streptozotocin-induced diabetic rats. Methods: The F. asafoetida extract (25, 50, and 100 mg/kg) was injected intraperitoneally to diabetic rats once daily for a 28-day period. The diabetic control group received the extract solvent as a vehicle by the same manner. Serum levels of glucose, triglycerides, cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were measured on the days 0, 17, and 31 of the intervention. In addition, animals’ weight changes were monitored during the experiment. Results: The F. asafoetida extract significantly reduced serum glucose, triglycerides, cholesterol, and LDL levels in diabetic rats, compared to the controls. Moreover, the weight-loss observed in diabetic animals receiving the extract was insignificant. The extract had no effect on the serum HDL level. Conclusions: Ferula asafoetida influenced serum glucose decrease and improved lipid profile in diabetic animals. However, further research should be conducted on the mechanisms of actions of F. asafoetida extract. | en |
| DOI | https://doi.org/10.5812/jjnpp.67042 | en |
| Keyword | <i>Ferula asafetida</i> | en |
| Keyword | Streptozotocin | en |
| Keyword | Diabetes Mellitus | en |
| Keyword | Glucose | en |
| Keyword | Lipid Profile | en |
| Keyword | Medicinal Plants | en |
| Publisher | Brieflands | en |
| Title | Effect of Ethyl Acetate Extract of <i>Ferula asafoetida</i> Oleo-Gum Resin on the Glucose Level and Lipid Profile in Streptozotocin-Induced Diabetic Rats | en |
| Type | Research Article | en |
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