Secondary Metabolites and Biological Activities of <i>Talaromyces sp. </i>LGT-2<i>, </i>an Endophytic Fungus from <i>Tripterygium Wilfordii</i>
| Author | Qiu-Hong Zhao | en |
| Author | Zhong-Duo Yang | en |
| Author | Zong-Mei Shu | en |
| Author | Yong-Gang Wang | en |
| Author | Ming-Gang Wang | en |
| Issued Date | 2016-07-31 | en |
| Abstract | In the present study, eleven compounds (1-11) including nine alkaloids (1-9), one triterpenoid saponin (10) and one formamide (11) were isolated from Talaromyces sp. LGT-2, an endophytic fungus from Tripterygium wilfordi. Their structures were determined based on NMR and ESI-MS spectral data, as well as comparing previous literature data. This is the first report of the isolation of alkaloids (1-9) from Talaromyces genus. In the next step, all compounds were screened for their anti-monoamine oxidase, anti-acetylcholinesterase, antibacterial and antitumor activities. Compound 11 showed moderate anti-monoamine oxidase activity with IC50 value of 61 μM; compounds 3, 4, 8 showed weaker anti-acetylcholinesterase activity; compounds 1, 3, 4, 7, 8, 9 showed moderate antibacterial activities; compounds 7, 8, 9 showed cytotoxicity against B16 cancer cell line with inhibitory rate of 86%, 82%, 78%, respectively, at the concentration of 500 μg/mL. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1873 | en |
| Keyword | endophytic fungus | en |
| Keyword | secondary metabolites | en |
| Keyword | monoamine oxidase inhibition | en |
| Keyword | <i>Talaromyces</i> | en |
| Keyword | <i>Tripterygium wilfordi</i> | en |
| Publisher | Brieflands | en |
| Title | Secondary Metabolites and Biological Activities of <i>Talaromyces sp. </i>LGT-2<i>, </i>an Endophytic Fungus from <i>Tripterygium Wilfordii</i> | en |
| Type | Original Article | en |
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