Synthesis, Characterization, and Cytotoxicity Evaluation of Methotrexate-Polyethylene Glycol-Glutamic Acid Nanoconjugate as Targeted Drug Delivery System in Cancer Treatment
| Author | Majid Ahmadi | en |
| Author | Katayoun Derakhshandeh | en |
| Author | Abbas H Azandaryani | en |
| Author | Hadi Adibi | en |
| Issued Date | 2022-06-30 | en |
| Abstract | Introduction: Methotrexate (MTX) is used as a folic acid antagonist in the treatment of many human cancers. Attachment of hydrophilic ligands to MTX improves its efficacy due to reducing toxicity and enzymatic degradation and it also increases its in-vivo half-life. | en |
| DOI | https://doi.org/10.4103/jrptps.JRPTPS_97_21 | en |
| Keyword | Chemotherapy | en |
| Keyword | drug delivery | en |
| Keyword | glutamic acid | en |
| Keyword | methotrexate | en |
| Keyword | nanoconjugate | en |
| Publisher | Brieflands | en |
| Title | Synthesis, Characterization, and Cytotoxicity Evaluation of Methotrexate-Polyethylene Glycol-Glutamic Acid Nanoconjugate as Targeted Drug Delivery System in Cancer Treatment | en |
| Type | Research Article | en |