Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats
| Author | Abbas Ahmadi | en |
| Author | Mohsen Khalili | en |
| Author | Ramin Hajikhani | en |
| Author | Leila Barghi | en |
| Author | Farnaz Mihandoust | en |
| Issued Date | 2010-10-31 | en |
| Abstract | Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with Ketamine and PCP. | en |
| DOI | https://doi.org/10.22037/ijpr.2010.903 | en |
| Keyword | Phencyclidine | en |
| Keyword | Ketamine | en |
| Keyword | 1-Tetralone derivatives | en |
| Keyword | Tail immersion test | en |
| Keyword | Formalin test | en |
| Keyword | Acute and chronic pain | en |
| Publisher | Brieflands | en |
| Title | Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats | en |
| Type | Original Article | en |
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