Effect of Combination Therapy of Methotrexate with Vitamin A in Patients with Low Risk GTN (Gestational Trophoblastic Neoplasia)
| Author | Sedigheh Ghasemian | en |
| Author | Zohreh Yousefi | en |
| Author | Marjaneh Farazestanian | en |
| Author | Leila Mousavi Seresht | en |
| Author | Mohsen Foroughipour | en |
| Author | Saeid Akhlaghi | en |
| Issued Date | 2018-03-31 | en |
| Abstract | Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (GTN) has been associated with high treatment rate. Combination of methotrexate with Vitamin A due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk GTN. Therefore, this study was performed with aim to determine the efficacy of combination therapy of Methotrexate with Vitamin A in low risk GTN treatment. This randomized clinical trial was performed on 49 patients with low risk gestational trophoblastic neoplasia. The treatment group (Group A = 19 cases) weekly received Methotrexate 50 mg/m2, and Vitamin A 200000 IU, intra-muscular, and the control group (Group B = 30 cases) only received Methotrexate 50 mg/m2 weekly. All patients were followed up for 8 weeks. Then, treatment outcomes were compared between two groups, and response to therapy was assessed in two groups by evaluation of HCG serum level. P < 0.05 was considered significant.Mean of B-HCG serum level after 4 weeks in Group A and Group B was 68.5 mIu/mL and 360 mIu/mL, respectively (P = 0.018), and after 8 weeks was 1 mIu/mL and 12 mIu/mL, respectively (P = 0.074). Combination therapy of Methotrexate and Vitamin A in low risk GTN is associated with shorter duration of chemotherapy. | en |
| DOI | https://doi.org/10.22037/ijpr.2018.2207 | en |
| URI | https://brieflands.com/journals/ijpr/articles/124725 | en |
| Keyword | Methotrexate | en |
| Keyword | Vitamin A | en |
| Keyword | Gestational Trophoblastic neoplasia (GTN) | en |
| Keyword | B-HCG | en |
| Keyword | Combination therapy. | en |
| Publisher | Brieflands | en |
| Title | Effect of Combination Therapy of Methotrexate with Vitamin A in Patients with Low Risk GTN (Gestational Trophoblastic Neoplasia) | en |
| Type | Original Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijpr-17-038.pdf
- Size:
- 260.21 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF