Association between VDR Gene Polymorphisms (<i>rs 1544410</i>, <i>rs 7975232</i>, <i>rs 2228570</i>, <i>rs 731236</i> and <i>rs 11568820</i>) and Susceptibility to Breast Cancer in a Sample of Southeastern Iranian Population
| Author | Seyed Mehdi Hashemi | en |
| Author | Narges Arbabi | en |
| Author | Mohammad Hashemi | en |
| Author | Mohammad Ali Mashhadi | en |
| Author | Abolghasem Allahyari | en |
| Author | Masoud Sadeghi | en |
| Orcid | Mohammad Hashemi [0000-0002-6074-7101] | en |
| Issued Date | 2017-03-31 | en |
| Abstract | Background: Vitamin D receptor (VDR) is a key nuclear receptor that is associated with the risk and progression of breast cancer (BC). Objectives: The present study investigated the Fok1, Bsm1, Taq1 and Cdx2 polymorphisms in the VDR gene and susceptibility to BC in a sample of Southeastern Iranian population. Methods: This case-control study was conducted on 180 women with BC and 178 age-matched healthy women. RFLP-PCR method was used for analysis of Bsm1 (rs 1544410), Apa1 (rs 7975232), Fok1 (rs 2228570) and Taq1 (rs 731236) and also TETRA-ARMS method for Cdx2 (rs 11568820). Results: No significant correlation was found between polymorphisms of Taq1, Fok1 and Apa1 with BC, but was for Bsm1 (odds ratio (OR) = 3.452, 95% CI 1.769 - 6.738; P < 0.001). Also, there was a significant correlation between the case and control groups for Cdx2 (OR = 3.720, 95% CI 2.224 - 6.225; P < 0.001) and allele A in Cdx2 had just significant correlation with BC. Conclusions: The present study findings showed that there were significant correlations between Bsm1 and Cdx2 polymorphisms with BC in women of Sistan and Baluchestan Province (southeastern Iran). Also, signals of Rs1544410-Bsm1 and Rs11568820-Cdx2 positions were difference with routes of estrogen and progesterone per person and they probably act independently. | en |
| DOI | https://doi.org/10.5812/ijcm.8807 | en |
| Keyword | Breast Cancer | en |
| Keyword | Polymorphism | en |
| Keyword | VDR | en |
| Keyword | Southeastern Iran | en |
| Publisher | Brieflands | en |
| Title | Association between VDR Gene Polymorphisms (<i>rs 1544410</i>, <i>rs 7975232</i>, <i>rs 2228570</i>, <i>rs 731236</i> and <i>rs 11568820</i>) and Susceptibility to Breast Cancer in a Sample of Southeastern Iranian Population | en |
| Type | Research Article | en |
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