Higher Serum Levels of Type I Interferon Receptor in Adults with Chronic Hepatitis B Leading to Hepatitis B Surface Antigen Clearance
| Author | Ashraf Mohamadkhani | en |
| Author | Sima Besharat | en |
| Author | Golnosh Gol-Jah Rad | en |
| Author | Akbar Pour Dadash Asiabar | en |
| Author | Gholamreza Roshandel | en |
| Author | Akram Pourshams | en |
| Author | Hossein Poustchi | en |
| Orcid | Hossein Poustchi [0000-0003-4566-3628] | en |
| Issued Date | 2017-03-01 | en |
| Abstract | Background: Loss of hepatitis B surface antigen (HBsAg) in chronic hepatitis B (CHB) infection is a favorable outcome. Type I interferon (IFNI) has an essential role to fight virus infections when they bind to the IFN-α/β receptor (IFNAR). Free-circulating IFNARs, known as IFNAR2, perform as carrier proteins to keep the ligands from proteolysis as well as antagonists for ligand binding. Objectives: In this study, we evaluated the HBsAg titer and IFNAR2 in serum baseline of a subcohort of Iranian HBeAg-negative patients with chronic hepatitis B. Methods: Sixty-four patients who spontaneously cleared HBsAg and 100 chronic hepatitis B patients enrolled in this study for assessment of the serum levels of HBsAg and IFNAR2. Results: Serum levels of HBsAg and IFNAR2 were both powerfully associated with loss of HBsAg. The baseline HBsAg titer was significantly lower (333.72 ± 1300 IU/mL vs 3811 ± 6779 IU/mL, P = 0.00) and the IFNAR2 serum level was significantly higher (1.64 ± 0.6 vs 0.87 ± 0.5 ng/mL, P = 0.00) in those who cleared HBsAg compared to the CHB patients. Conclusions: These findings indicated the association of the HBsAg titer and serum IFNAR2 in HBsAg clearance in hepatitis B virus- infected patients. In consequence, immune mechanisms related to IFN-α/β signaling might be responsible in CHB outcome. | en |
| DOI | https://doi.org/10.5812/jjm.41319 | en |
| Keyword | Chronic Hepatitis B | en |
| Keyword | Hepatitis B Surface Antigens | en |
| Keyword | Interferon Alpha-Beta Receptor | en |
| Keyword | Cohort Study | en |
| Publisher | Brieflands | en |
| Title | Higher Serum Levels of Type I Interferon Receptor in Adults with Chronic Hepatitis B Leading to Hepatitis B Surface Antigen Clearance | en |
| Type | Research Article | en |
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