Fibroblast Growth Factor 1 Gene-Transfected Adipose-Derived Mesenchymal Stem Cells Modulate Apoptosis And Inflammation In The Chronic Constriction Injury Model of Neuropathic Pain
| Author | Fatemeh Forouzanfar | en |
| Author | Hamid R Sadeghnia | en |
| Author | Seyed Javad Hoseini | en |
| Author | Ahmad Ghorbani | en |
| Author | Hamed Ghazavi | en |
| Author | Faezeh Ghasemi | en |
| Author | Hossein Hosseinzadeh | en |
| Issued Date | 2020-10-31 | en |
| Abstract | Stem cell therapy is noted for its clinical effect in the treatment of neuropathic pain. This study aimed to investigate the potential anti-apoptotic and anti-inflammatory effects of adipose-derived mesenchymal stem cells (AD-MSCs) and fibroblast growth factor 1 gene-transfected adipose-derived mesenchymal stem cells (AD-MSCs FGF1) on chronic constriction injury (CCI) of the rat’s sciatic nerve. The rats that underwent CCI were treated with AD-MSCs and AD-MSCs FGF1. Bax, Bcl2, and caspases 3, the major contributors of apoptosis, and inflammatory markers including Iba-1, IL1-β, and MMP-2 were evaluated in the lumbar portion (L4-L6) of the spinal cord through western bloating at days 3 and 14. The ratio of Bax/Bcl2, cleaved caspases 3, MMP-2, IL-1β, and Iba1, was elevated in CCI animals compared to sham-operated animals and decreased following treatment with both AD-MSCs and AD-MSCs FGF1. However, the effect of AD-MSCs FGF1 was significantly higher than AD-MSCs. These data suggest that the administration of AD-MSCs FGF1 through modulating apoptosis and neuroinflammation could be considered a promising medicine for treating neuropathic pain. | en |
| DOI | https://doi.org/10.22037/ijpr.2020.113223.14176 | en |
| URI | https://brieflands.com/journals/ijpr/articles/124676 | en |
| Keyword | Adipose-derived mesenchymal stem cell | en |
| Keyword | Fibroblast growth factor 1 | en |
| Keyword | Transfection | en |
| Keyword | Neuropathic pain | en |
| Publisher | Brieflands | en |
| Title | Fibroblast Growth Factor 1 Gene-Transfected Adipose-Derived Mesenchymal Stem Cells Modulate Apoptosis And Inflammation In The Chronic Constriction Injury Model of Neuropathic Pain | en |
| Type | Original Article | en |
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