Antimicrobial Resistance, Integron Carriage, and Fluoroquinolone Resistance Genes in <i>Acinetobacte baumannii</i> Isolates
| Author | Parastoo Ashouri | en |
| Author | Jafar Mohammadshahi | en |
| Author | Vajihe Sadat Nikbin | en |
| Author | Hadi Peeridogaheh | en |
| Author | Behnam Mohammadi-Ghalehbin | en |
| Author | Soheila Refahi | en |
| Author | Amir Teimourpour | en |
| Author | Majid Esmaelizad | en |
| Author | Hafez Mirzaneghad | en |
| Author | Roghayeh Teimourpour | en |
| Orcid | Jafar Mohammadshahi [0000-0001-9862-4118] | en |
| Issued Date | 2022-10-31 | en |
| Abstract | Background: Acinetobacte is the leading cause of pneumonia and sepsis in the ICU ward. Accordingly, in the present study, the antibiotic susceptibility pattern, presence, and dissemination of different classes of integrons and fluoroquinolone resistance genes were investigated among A. baumannii isolates. Methods: In this descriptive, cross-sectional study, during a period of 24 months (2018 - 2020), 100 isolates of A. baumannii were isolated from different clinical specimens of patients admitted to the two teaching hospital in Ardabil province in the northwest of Iran. Kirby -Bauer disk diffusion, PCR, and sequencing methods were used for antimicrobial susceptibility testing and gene and mutation verification. Results: The resistance rates to all tested antibiotics were found to be between 78% and 100%. No isolate was resistant to polymyxin B. Multidrug-resistant (MDR) rate among tested clinical isolates was about 99%. The prevalence of class 1, 2, and 3 integrons was found to be 70%, 21%, and 0%, respectively. The aadA1 cassette gene was detected in all class 1 integron-carrying strains. Conclusions: High-level antibiotic resistance and a high prevalence of integrons were observed among these clinical isolates. Our findings highlighted the need for continuous monitoring of resistant isolates. | en |
| DOI | https://doi.org/10.5812/archcid-120590 | en |
| Keyword | <i>Acinetobacte baumannii</i> | en |
| Keyword | ICU | en |
| Keyword | Pneumonia | en |
| Keyword | Urinary Tract Infection | en |
| Keyword | Integron | en |
| Publisher | Brieflands | en |
| Title | Antimicrobial Resistance, Integron Carriage, and Fluoroquinolone Resistance Genes in <i>Acinetobacte baumannii</i> Isolates | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- archcid-17-5-120590.pdf
- Size:
- 717.3 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF