THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT
| Author | A Arzi | en |
| Author | AA Hemmati | en |
| Author | S Ghobishavi | en |
| Author | L Arzi | en |
| Issued Date | 2007-03-30 | en |
| Abstract | Catatonia is one of the major signs of parkinson’s disease which is due to impaired dopamine in extrapyrmidal system. This study was performed to elucidate the role of L-tyrosine, vitamin E and vitamin C on perphenazine-induced catatonia in model of rat. Eight groups of rats were pretreated orally by a single dose of L-tyrosine (1500 mg/kg), vitamin E (250 mg/kg), vitamin C (300 mg/kg), vitamin E plus vitamin C, vitamin E plus L-tyrosine, vitamin C plus L-tyrosine, vitamins E and C plus L-tyrosine and normal saline (control group) for two weeks, respectively. One hour after the last dose, perphenazine (5 mg/kg) was administered (IP) to induce catatonia. Muscular rigidity of animals was determined by scoring method of Morpurgo. The results of this study indicate that L-tyrosine plus vitamins E and C could reduce the perphenazine-induced muscular rigidity better than other groups. | en |
| DOI | https://doi.org/ | en |
| URI | https://brieflands.com/journals/jjnpp/articles/72404 | en |
| Keyword | L-tyrosine | en |
| Keyword | Vitamin E | en |
| Keyword | Vitamin C | en |
| Keyword | Perphenazine | en |
| Keyword | Catatonia | en |
| Keyword | Rat. | en |
| Publisher | Brieflands | en |
| Title | THE EFFECT OF L-TYROSINE, VITAMINS E AND C ON PERPHENAZINE-INDUCED CATATONIA IN RAT | en |
| Type | Research Article | en |
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