Evaluation of In Vitro Antimalarial Activity of Different Extracts of <i>Eremostachys azerbaijanica</i> Rech.f.
| Author | Solmaz Asnaashari | en |
| Author | Fariba Heshmati Afshar | en |
| Author | Sedigheh Bamdad Moghadam | en |
| Author | Abbas Delazar | en |
| Issued Date | 2016-07-31 | en |
| Abstract | Six extracts with different polarity from aerial parts and rhizomes of Eremostachys azerbaijanica Rech.f., were screened for their antimalarial properties by cell free 𝛽-hematin formation assay. Dichloromethane (DCM) extracts of both parts of plant showed significant antimalarial activities with IC50 values of 0.949 ± 0.061 mg/mL in aerial parts and 0.382 ± 0.011 mg/mL in rhizomes. Bioactivity-guided fractionation of the most potent part (DCM extract of rhizomes) by vacuum liquid chromatography (VLC) afforded seven fractions. Two fractions [100% Ethyl acetate (EtOAC) and 100% Methatol (MeOH)] showed considerable antimalarial activity with IC50 values of 0.335 ± 0.033 mg/mL and 0.403 ± 0.037 mg/mL, respectively. | en |
| DOI | https://doi.org/10.22037/ijpr.2016.1893 | en |
| Keyword | Antimalaria | en |
| Keyword | <i>Eremostachys azerbaijanica</i> | en |
| Keyword | Cell free assay | en |
| Keyword | GC-MS | en |
| Publisher | Brieflands | en |
| Title | Evaluation of In Vitro Antimalarial Activity of Different Extracts of <i>Eremostachys azerbaijanica</i> Rech.f. | en |
| Type | Original Article | en |