Solubility of Naproxen in Polyethylene Glycol 200 + Water Mixtures at Various Temperatures
| Author | Vahid Panahi-Azar | en |
| Author | Shahla Soltanpour | en |
| Author | Fleming Martinez | en |
| Author | Abolghasem Jouyban | en |
| Issued Date | 2015-10-31 | en |
| Abstract | The solubility of naproxen in binary mixtures of polyethylene glycol 200 (PEG 200) + water at the temperature range from 298.0 K to 318.0 K were reported. The combinations of Jouyban-Acree model + van’t Hoff and Jouyban-Acree model + partial solubility parameters were used to predict the solubility of naproxen in PEG 200 + water mixtures at different temperatures. Combination of Jouyban-Acree model with van’t Hoff equation can be used to predict solubility in PEG 200 + water with only four solubility data in mono-solvents. The obtained solubility calculation errors vary from ~ 17 % up to 35 % depend on the number of required input data. Non-linear enthalpy-entropy compensation was found for naproxen in the investigated solvent system and the Jouyban−Acree model provides reasonably accurate mathematical descriptions of the thermodynamic data of naproxen in the investigated binary solvent systems. | en |
| DOI | https://doi.org/10.22037/ijpr.2015.1750 | en |
| URI | https://brieflands.com/journals/ijpr/articles/125402 | en |
| Keyword | Thermodynamic analysis | en |
| Keyword | Solubility | en |
| Keyword | Naproxen | en |
| Keyword | Jouyban–acree model | en |
| Publisher | Brieflands | en |
| Title | Solubility of Naproxen in Polyethylene Glycol 200 + Water Mixtures at Various Temperatures | en |
| Type | Original Article | en |
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