The Effects of Chlorpyrifos on Hippocampal Caspase-3 Levels and Passive Avoidance Memory in Rats
| Author | Sina Nikbin | en |
| Author | Seyed Behnamedin Jameie | en |
| Author | Mohammad Ali Azarbayjani | en |
| Author | Nasrin Hosseini | en |
| Orcid | Mohammad Ali Azarbayjani [0000-0002-3502-7487] | en |
| Issued Date | 2022-06-30 | en |
| Abstract | Background: Chlorpyrifos is an organophosphate pesticide that is widely used in the world. Exposure to chlorpyrifos is associated with some problems in cognitive functions, such as learning and memory. Caspase-3 is a cysteine protease that is activated in response to several apoptotic stimuli and triggers some proteolytic events, cell death, and neurodegeneration. Objectives: The aim of the present study was to clear potential mechanisms related to chlorpyrifos neurotoxicity through caspase-3 alteration and passive avoidance memory function. Methods: Male adult rats were randomly divided into the control, sham, and chlorpyrifos groups (eight rats in each group). The chlorpyrifos group received an intraperitoneal injection of chlorpyrifos (3 mg/kg/5 days) dissolved in dimethyl sulfoxide for two consecutive weeks. The caspase-3 levels in the hippocampus were assessed by the western blot technique, and also the passive avoidance task was used for memory evaluation. Results: Our findings showed that chlorpyrifos treatment markedly increased caspase-3 levels in the hippocampus and also increased the time spent in the dark chamber 24 h and one week after receiving foot shock in the chlorpyrifos group. Conclusions: Organophosphate pesticides exposure can impair passive avoidance memory, and high levels of caspase-3 in the hippocampus are proposed as a possible reason for neuronal toxicity and memory impairment. | en |
| DOI | https://doi.org/10.5812/thrita-123356 | en |
| Keyword | Organophosphates | en |
| Keyword | Caspase-3 | en |
| Keyword | Passive Avoidance | en |
| Keyword | Memory | en |
| Publisher | Brieflands | en |
| Title | The Effects of Chlorpyrifos on Hippocampal Caspase-3 Levels and Passive Avoidance Memory in Rats | en |
| Type | Research Article | en |
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