Mucoadhesive Electrospun Nanofibers of Chitosan/Gelatin Containing Vancomycin as a Delivery System

Abstract

Mucoadhesive oral delivery systems have been of interest to researchers because of improving bioavailability and patient compliance by increasing concentration gradient. This study aimed to investigate local delivery of vancomycin using against gram-positive bacteria. Vancomycin is not absorbed from the gastrointestinal tract, so it will be given by injection. Also, slow infusion of vancomycin in blood is so vital to reduce its severe side effects and is excreted through the urine. Controlled dose of vancomycin can reduce drug resistance. Here in, a blend of chitosan and gelatin loaded with vancomycin was electrospun. The obtained nanofibers were characterized by FTIR, UV and SEM. The swelling and stability of the nanofibers were evaluated. In vitro release of the vancomycin was measured over a 72-hours period by total immersion method. The average diameter of drug-loaded nanofiber was 384 nm. The release behavior of the optimum fibrous mat conform Higuchi kinetic model.