Cyclodextrins in Skin Formulations and Transdermal Delivery

Abstract

This mini review aims to describe the main physicochemical properties and characteristics of cyclodextrin derivatives (CDs) having been used in various skin-related formulations over the last nearly 50 years. Due to many misunderstandings and inconsistent data on the Internet, the basic properties of CDs, water content, solubility properties, and maximum complexing capabilities are summarized. CDs are grouped by their solubility properties and briefly described by chemical synthesis to reveal the potential contaminants. Soluble and insoluble CD-based polymers are also discussed.