Effect of D-003, a Mixture of High Molecular Weight Aliphatic Acids, on Glucocorticoid- and Lipopolysaccharides (LPS)-Induced Osteonecrosis
| Author | Miriam Noa | en |
| Author | Rosa Más | en |
| Author | Maikel Valle | en |
| Author | Sarahí Mendoza | en |
| Author | Nilda Mendoza | en |
| Issued Date | 2012-10-31 | en |
| Abstract | Osteonecrosis (ON) is characterized through the impairment of osseous blood flow that leads to the collapse of femur head. Corticoid-induced ON in rats and lipopolysaccharide (LPS)-induced in rabbits are useful models to assess the efficacy of potential treatments on this disease. D-003 inhibits the mevalonate pathway, lipid peroxidation and prevents osteoporosis in rats through increasing the osteoclast apoptosis. This study investigated the effects of D-003 on corticoid- and LPS-induced ON in rats and rabbits. | en |
| DOI | https://doi.org/10.22037/ijpr.2012.1157 | en |
| Keyword | D-003 | en |
| Keyword | Osteonecrosis | en |
| Keyword | Glucocorticoid | en |
| Keyword | Lipopolysaccharides | en |
| Publisher | Brieflands | en |
| Title | Effect of D-003, a Mixture of High Molecular Weight Aliphatic Acids, on Glucocorticoid- and Lipopolysaccharides (LPS)-Induced Osteonecrosis | en |
| Type | Original Article | en |
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