The Inflammatory Indicator IL-6 and BDNF Levels in Male Fitness Athletes and Their Relationship with Acute Stress Disorder: A Case-Control Study
| Author | Tiam Asadi | en |
| Author | Mohammad Reza Mohammadi | en |
| Author | Seyed-Ali Mostafavi | en |
| Orcid | Mohammad Reza Mohammadi [0000-0002-7061-5938] | en |
| Orcid | Seyed-Ali Mostafavi [0000-0002-8008-3824] | en |
| Issued Date | 2025-12-31 | en |
| Abstract | Background: The responses of the inflammatory marker interleukin 6 (IL-6) and brain-derived neurotrophic factor (BDNF) to acute stress in fitness athletes are unknown. Objectives: This study aimed to investigate IL-6 and BDNF levels in male fitness athletes and their association with acute stress disorder using a case-control design. Methods: Ninety male fitness athletes were divided into a case group (individuals with acute stress disorder) and a control group (individuals without acute stress disorder) using a psychological diagnostic interview based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria, conducted by a clinical psychologist to reduce selection bias. Serum IL-6 and BDNF samples were collected at two time points, before and after muscular training. Data were analyzed using t tests and binary logistic regression. Results: After controlling for anxiety and depression, the association between IL-6 and acute stress disorder before muscular training was positive and significant (OR = 1.013; 95% CI, 1.003 to 1.022; P = 0.007). After muscular training, this association became negative and significant relative to the control group (OR = 0.975; 95% CI, 0.961 to 0.990; P = 0.001). Notably, after muscular training, there was a very strong positive association between BDNF and acute stress disorder (OR = 10.328; 95% CI, 1.585 to 67.318; p = 0.015). Muscular exercise increased serum IL-6 levels in the nonstressed group (mean change, 26.49 ± 39.18; P ≤ 0.001) but decreased IL-6 levels in the acute stress disorder group, which already had high serum levels (mean change, -56.87 ± 46.83; P ≤ 0.001). Conclusions: Muscular exercise increased BDNF levels in both groups. Acute stress disorder was significantly associated with increased IL-6 and BDNF levels in male fitness athletes. After physical exercise, IL-6 levels decreased, whereas BDNF levels increased. These findings are limited to male athletes. | en |
| DOI | https://doi.org/10.5812/asjsm-169563 | en |
| URI | https://brieflands.com/journals/asjsm/articles/169563 | en |
| Keyword | Inflammatory Markers | en |
| Keyword | Interleukin-6 | en |
| Keyword | BDNF | en |
| Keyword | Fitness Athletes | en |
| Keyword | Acute Stress Disorder | en |
| Publisher | Brieflands | en |
| Title | The Inflammatory Indicator IL-6 and BDNF Levels in Male Fitness Athletes and Their Relationship with Acute Stress Disorder: A Case-Control Study | en |
| Type | Research Article | en |
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