Investigation of Mitochondrial Common Deletion and BRCA Mutations for Detection of Familial Breast Cancers in Archival Breast Cancer Materials

Abstract

Bachground and Aim: Mutation analysis of mitochondrial genome and BRCA genes are helpful in the early diagnosis of familial breast cancers. In this study, we investigated mitochondrial common deletion and BRCA mutations through multiplex PCR and clinical parameters for the detection of familial breast cancers in archival breast cancer samples.