The Effect of Ethanol Baneh Skin Extract on the Expressions of Bcl - 2, Bax, and Caspase - 3 Concentration in Human Prostate Cancer pc3 Cells
| Author | Maryam Amiri | en |
| Author | Foad Nasrollahi | en |
| Author | Siamak Barghi | en |
| Author | Nazanin Ebrahimi | en |
| Author | Afsaneh Rajizadeh | en |
| Author | Nasrin Dehghan Nayyeri | en |
| Author | Faranak Kazerouni | en |
| Author | Ali Rahimipour | en |
| Author | Saeed Namaki | en |
| Author | Hadis Ahmadi | en |
| Orcid | Faranak Kazerouni [0000-0002-1022-0053] | en |
| Issued Date | 2018-03-31 | en |
| Abstract | Background: Traditional herbs are effective in the treatment of many diseases. It is proven that traditional herbs can decrease the risk of cancer and grow the survivals of patients. Objectives: Based on the results of our previous research, ethanol Baneh skin extract has cytotoxic effect on pc3 cells; thus, we decide to determine the effect of Baneh extracts on Bcl2 and Bax expression and amount of concentration of caspase3. Methods: The expressions of apoptotic - related genes were determined by real time PCR and the concentration of caspase3 was determined by ELISA method. Results: Ethanol Baneh skin extract increased the mRNA expression of Bax and decreased the mRNA expression of Bcl2 in pc3 cells and also increased the amount of caspase3. Conclusions: The result of this study indicates the Ethanol Baneh skin extract including photochemical that might be a candidate for the herbal anti - cancer drugs. | en |
| DOI | https://doi.org/10.5812/ijcm.9865 | en |
| Keyword | Expression of Bax and Bcl - 2 | en |
| Keyword | Concentration of Caspase3 | en |
| Keyword | Prostate Cancer | en |
| Keyword | Ethanol Baneh Skin Extract | en |
| Publisher | Brieflands | en |
| Title | The Effect of Ethanol Baneh Skin Extract on the Expressions of Bcl - 2, Bax, and Caspase - 3 Concentration in Human Prostate Cancer pc3 Cells | en |
| Type | Research Article | en |
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