SiO2/H2SO4: An Efficient Catalytic System for Solvent-free 1, 5-benzodiazepines Synthesis
| Author | Mohammad Reza Shushizadeh | en |
| Author | Narges Dalband | en |
| Orcid | Mohammad Reza Shushizadeh [0000-0002-7411-8947] | en |
| Issued Date | 2012-05-28 | en |
| Abstract | Background: 1, 5-Benzodiazepines have been investigated extensively by organic chemists due to their medicinal and pharmacological properties. These compounds are synthesized by condensation of o-phenylenediamines with carbonyl compounds in the presence of acid catalysts. Objectives: During our studies on the application of silica resin with acid functional moieties, we found that SiO2/H2SO4 mixture is a simple and efficient catalyst for this method under microwave irradiation. Materials and Methods: The reaction was carried out simply by grinding SiO2/H2SO4 mixture with o-phenylenediamine, and ketone in the mortar; then the mixture was poured out into a sealed flask. Subsequently, it was irradiated in a microwave oven. Results: In this method a series of cyclic and acyclic ketones underwent above conversion to form corresponding 1, 5-benzodiazepines. Conclusions: In conclusion, this method is a simple, rapid, and high yielding reaction (78–95%). | en |
| DOI | https://doi.org/10.17795/jjnpp-3624 | en |
| Keyword | Sulfuric acid | en |
| Keyword | Ketones | en |
| Keyword | 1 | en |
| Keyword | 2-diaminobenzene | en |
| Keyword | Microwave | en |
| Keyword | Radiotherapy | en |
| Publisher | Brieflands | en |
| Title | SiO2/H2SO4: An Efficient Catalytic System for Solvent-free 1, 5-benzodiazepines Synthesis | en |
| Type | Research Article | en |
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