Effect of Tizanidine, Rilmenidine, and Yohimbine on Naloxon-Induced Morphine Withdrawal Syndrome in Mice

Abstract

In this study using clonidine (a mixed α2 /I1 receptors agonist), tizanidine (pure α2-receptor agonist), rilmenidine (I1 receptor agonist) and yohimbine (α2-receptor antagonist), we tried to clarify the role of imidazoline and α2-receptors in morphine withdrawal syndrome.