A Common SNP of IL-10 (-1082A/G) is Associated With Increased Risk of Premenopausal Breast Cancer in South Indian Women
| Author | Cingeetham Vinod | en |
| Author | Akka Jyothy | en |
| Author | Malladi Vijay kumar | en |
| Author | Ramaiyer Raghu Raman | en |
| Author | Pratibha Nallari | en |
| Author | Ananthapur Venkateshwari | en |
| Issued Date | 2015-08-28 | en |
| Abstract | Background:: Evading the immune destruction and angiogenesis has been the two hallmarks of cancer. Interleukin-10 (IL-10) is a cytokine with immune suppressing (pro-tumorigenic) and anti-angiogenic (anti-tumorigenic) properties, thus making the role of IL-10 in tumorigenesis enigmatic. Previous studies have suggested a critical role of IL10 altered expression in complex process of tumor-microenvironment, co-evolution and tumorigenesis. Objectives:: Evaluating the role of IL10 (-1082A/G) gene promoter polymorphism in breast cancer patients from South India. Patients and Methods:: A case-control study was conducted with a total of 285 individuals, these include 125 histologically confirmed breast cancer patients and 160 age and sex matched controls. Genotypes were determined by allele-specific polymerase chain reaction (AS-PCR), followed by agarose gel electrophoresis. Statistical analysis was done to test the significance of results obtained. Results:: Statistical analysis revealed that AA genotype of the Il-10 -1082A/G polymorphism is significantly associated with breast cancer (AA vs. AG: χ2 = 14.46, P = 0.0001432, OR = 2.854, 95% CI = 1.68 - 4.849). Up on stratifying subjects based on cancer stage, age at onset, menopausal status, AA genotype has associated with all the sub groups, except for post-menopausal women. There was no significant association which was observed with respected to hormonal status (ER, PR) and Her2/neu status. Conclusions:: The present study suggests that IL-10 AA genotype as a risk factor in the etiology of breast cancer in the South Indian population. | en |
| DOI | https://doi.org/10.17795/ijcp-3434 | en |
| Keyword | Interleukin-10 | en |
| Keyword | Polymorphism | en |
| Keyword | Breast Cancer | en |
| Keyword | Allele Specific Polymerase Chain Reaction | en |
| Publisher | Brieflands | en |
| Title | A Common SNP of IL-10 (-1082A/G) is Associated With Increased Risk of Premenopausal Breast Cancer in South Indian Women | en |
| Type | Research Article | en |
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