Virologic Failure in Different Antiretroviral Regimens Among Pediatric Patients with HIV Referring to a Voluntary Counseling and Testing (VCT) Center in Tehran, Iran (2004 - 2017)
| Author | Mehrnaz Rasoolinejad | en |
| Author | Mohammad Sarraf | en |
| Author | Zeinab Najafi | en |
| Author | SeyedAhmad SeyedAlinaghi | en |
| Author | Banafsheh Moradmand Badie | en |
| Author | Mohammadreza Salehi | en |
| Author | Fabricio Azevedo Voltarelli | en |
| Orcid | SeyedAhmad SeyedAlinaghi [0000-0003-3210-7905] | en |
| Orcid | Mohammadreza Salehi [0000-0002-1987-5929] | en |
| Issued Date | 2019-10-31 | en |
| Abstract | Objectives: This study aimed to evaluate the virologic failure rate of treatment for various types of antiretroviral treatment (ART) regimens in pediatric patients with HIV. Methods: The present study was conducted among 75 HIV-positive pediatric patients characterized by the presence of a viral load of 200 or more copies per mL after six months of effective, continuous ART regimen. Therefore, treatment failure was defined based on virologic failure. We designed a questionnaire that included patients’ demographic characteristics, viral load markers, TCD4+ count, antiretroviral regimen received, and the probable treatment failure, along with the results of the drug resistance tests. Results: In total, 22 (29.2%) children experienced treatment failure. The most common primary antiretroviral regimen was Zidovudine (AZT)/Lamivudine (3TC)/Nevirapine (NVP) (59.2%), followed by AZT/3TC/Efavirenz (EFV) (29.6%). The highest rate of virologic failure was related to the AZT/3TC/NVP regimen (68.2%). In children who used NVP, the virologic failure was significantly higher than in children on other regimens (P = 0.02). Conclusions: The present study showed that patients receiving ART regimens based on reverse transcriptase non-nucleoside inhibitors, especially NVP, experienced more treatment failure than patients receiving other regimens. | en |
| DOI | https://doi.org/10.5812/pedinfect.80318 | en |
| Keyword | HIV/AIDS | en |
| Keyword | Pediatric | en |
| Keyword | Virologic Failure | en |
| Keyword | Antiretroviral Therapy | en |
| Keyword | Iran | en |
| Publisher | Brieflands | en |
| Title | Virologic Failure in Different Antiretroviral Regimens Among Pediatric Patients with HIV Referring to a Voluntary Counseling and Testing (VCT) Center in Tehran, Iran (2004 - 2017) | en |
| Type | Research Article | en |
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