Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease
| Author | Mohammad Hashemi | en |
| Author | Hamideh Hanafi Bojd | en |
| Author | Ebrahim Eskandari Nasab | en |
| Author | Ali Bahari | en |
| Author | Noor Allah Hashemzehi | en |
| Author | Sara Shafieipour | en |
| Author | Behzad Narouie | en |
| Author | Mohsen Taheri | en |
| Author | Saeid Ghavami | en |
| Orcid | Mohammad Hashemi [0000-0002-6074-7101] | en |
| Issued Date | 2013-05-01 | en |
| Abstract | Background: Genetic and environmental factors are important for the development of nonalcoholic fatty liver disease (NAFLD). Adiponectin is a white and brown adipose tissue hormone, and have been found to play essential roles in the regulation of energy homoeostasis. Recent reports have identified a possible role of adiponectin in NAFLD via PPARγ pathway. Objectives: The present study was designed to find out the impact of adiponectin rs1501299 (276G/T) and rs266729 (-11377C/G) gene polymorphisms in NAFLD. Patients and Methods: Eighty-three patients with diagnosis of NAFLD, and 93 healthy subjects were included in the study. Tetra ARMS-PCR was designed to detect single nucleotide polymorphisms. Results: A significant difference was found between NAFLD and control group regarding the rs266729 polymorphism (χ2 = 7.35, P = 0.025). The rs266729 polymorphism increased the risk of NAFLD in codominant (CC vs. CG: OR = 2.18, 95% CI = 1.16 - 4.12, P = 0.016) and dominant (CC vs. CG/GG: OR = 2.31, 95% CI = 1.25 - 4.27; P = 0.008) inheritance tested models. The G allele increased the risk of NAFLD (OR = 1.63, 95% CI = 1.03 - 2.57, P = 0.037) in comparison with C allele. No significant difference was found between the groups concerning adiponectin rs1501299 gene polymorphism (χ2 = 0.70, P = 0.697). Conclusions: adiponectin rs266729 polymorphism might be a candidate gene, which determines the susceptibility to NAFLD. Larger studies are necessary to confirm these findings in various populations. | en |
| DOI | https://doi.org/10.5812/hepatmon.9527 | en |
| Keyword | Fatty Liver | en |
| Keyword | Adiponectin | en |
| Keyword | Polymorphism | en |
| Publisher | Brieflands | en |
| Title | Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease | en |
| Type | Research Article | en |
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