The Antimicrobial Activity of Ferula Gummosa on Bacterial Strains Isolated from Patients with Gastroenteritis

Abstract

Objective: Ferula gummosa grows as a native plant in different parts of Iran and has been used for treatment of some infections such as UTI since ancient times. Present study is planned to show the antibacterial effect of this herb on bacteria isolated from infectious diarrhea. Patients and Methods: Extracts of the plant were achieved using maceration method. The concentration of 0.2gr/ml was used against pathogenic bacteria causing gastroenteritis; isolated from patients admitted to Shahid Beheshti University of Medical Sciences Hospitals and also minimum inhibitory concentration (MIC) of the extract was determined. Results: The highest value of MIC was due to Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae and even Pseudomonas with 1/1024 dilution liter. Three antibiotics of tetracycline, trimethoprim and ciprofloxacin were also tested against the bacteria. The highest MIC was in 1/1000 mg/ml of ciprofloxacin and was against Pseudomonas aeruginosa and Serratia marcescens with MIC dilution of 21 . Conclusion: According to our findings, it is recommended to use Ferula gummosa extract, as a herbal alternative treatment, in more investigations to prove its treatment effects on infections.