The Effect of <i>Vitis vinifera </i>L. Leaves Extract on <i>Leishmania infantum</i>

AuthorRym Mansouren
AuthorNajoua Haouasen
AuthorAmel Ben Kahla-Nakbien
AuthorSaoussen Hammamien
AuthorZine Mighrien
AuthorFarouk Mhennien
AuthorHamouda Babbaen
Issued Date2013-07-31en
AbstractVitis vinifera L.is a traditional Asian herb widely used for different health problems. In the present research, the ethanolic and the aqueous extracts of Vitis vinifera L. leaves collected from shrub, grown in Tunisia, were prepared and evaluated for the antileishmanial activity against Leishmani ainfantum promastigotes. The inhibitory concentration 50 (IC50) was determined and the results showed that the etahnolic extract is more active than the aqueous one (IC50= 0.108 mg/mL). Microscopic observations showed that the ethanolic extract promoted the destruction of cytoplasmic and nuclear membranes of Leishmani ainfantum promastigotes and altered the overall shape of the cell. In order to explain the difference of antileishmanial activity between ethanolic and aqueous extracts, anthocyanins amount was determined by spectrophotometry. It was found that the ethanolic extract is richer in anthocyanins than the aqueous one which can explain the higher antileishmanial activity of the ethanolic extract.en
DOIhttps://doi.org/10.22037/ijpr.2013.1333en
Keyword<i>Vitis vinifera </i>L.en
KeywordExtractionen
KeywordLeishmaniasisen
KeywordAntileishmanial activityen
KeywordAnthocyaninsen
PublisherBrieflandsen
TitleThe Effect of <i>Vitis vinifera </i>L. Leaves Extract on <i>Leishmania infantum</i>en
TypeOriginal Articleen

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
ijpr-12-349.pdf
Size:
983.63 KB
Format:
Adobe Portable Document Format
Description:
Article/s PDF