Facile Synthesis and Characterization of Ibuprofen-mesoporous Hydroxyapatite Nanohybrid as a Sustained Drug Delivery System
| Author | Zahra Namazi | en |
| Author | Tahereh Sadat Jafarzadeh Kashi | en |
| Author | Mohammad Erfan | en |
| Author | Farhood Najafi | en |
| Author | Leila Bakhtiari | en |
| Author | Seyed Rohola Ghodsi | en |
| Author | Hassan Farhadnejad | en |
| Issued Date | 2019-07-31 | en |
| Abstract | The present study deals with the fabrication of ibuprofen-mesoporous hydroxyapatite (IBU-MHA) particles via the incorporation of ibuprofen (IBU)—as a nonsteroidal anti-inflammatory drug—into mesoporous hydroxyapatite nanoparticles (MHANPs) using an impregnation process, as a novel drug delivery device. MHANPs were synthesized by a self-assembly process using cetyltrimethylammonium bromide (CTAB) as a cationic surfactant and 1-dodecanethiol as a pore expander under basic condition. The focus of the present study was to optimize the incorporation of IBU molecules into MHANPs under different loading conditions. The synthesized MHANPs and IBU-MHA particles were confirmed by X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), brunauer–emmett–teller (BET), transmission electron microscopy (TEM), and thermal analysis (TGA). Drug loading (DL) efficiency of IBU-MHA particles was determined by ultraviolet–visible (UV-Vis) spectroscopy, and indicated that the optimized IBU-MHA particles with high DL (34.5%) can be obtained at an IBU/ MHANPs ratio of 35/50 (mg/mg), impregnation period of 24 h, and temperature of 40 °C using ethanol as solvent. In-vitro drug release test was carried out to prove the efficiency of IBU-MHA particles as a sustained drug delivery system. A more sustained and controlled drug release was observed for this particles, indicating that it may be have good potential as drug reservoirs for local drug release. | en |
| DOI | https://doi.org/10.22037/ijpr.2019.1100769 | en |
| Keyword | Mesoporous | en |
| Keyword | Nanoparticle | en |
| Keyword | Hydroxyapatite | en |
| Keyword | Ibuprofen | en |
| Keyword | Drug Delivery | en |
| Publisher | Brieflands | en |
| Title | Facile Synthesis and Characterization of Ibuprofen-mesoporous Hydroxyapatite Nanohybrid as a Sustained Drug Delivery System | en |
| Type | Original Article | en |