Preparation and Characterization of Liposomes Containing Essential Oil of Eucalyptus camaldulensis Leaf
| Author | Eskandar Moghimipour | en |
| Author | Nasrin Aghel | en |
| Author | Ali Zarei Mahmoudabadi | en |
| Author | Zahra Ramezani | en |
| Author | Somayeh Handali | en |
| Issued Date | 2012-08-25 | en |
| Abstract | Background: The increased incidence of fungal resistance has necessitated the need to search for new antifungal agents. Objective: The main objectives of the present study were to investigate the effectiveness of the essential oil of Eucalyptus camaldulensis on dermatophytes growth and to formulate and characterize a liposomal gel loaded with the essential oil. Materials and Methods: The essential oil extracted from the leaves of E. camaldulensis was analyzed by GC-MS. The antifungal activity of this essential oil was determined against Microsporum canis, M. gypseum, Trichophyton rubrum and T. verrucosum, using the well diffusion method. Liposomes were prepared by the freeze-thaw method and evaluation of size distribution was performed using a particle size analyzer. The liposomal gel was prepared using ‘hydroxethyl cellulose (HEC) as the gelling agent. The rheologic characteristics were determined by a Brookfield viscometer. Results: The results showed that the minimum inhibitory volume of the essential oil was 0.125 ml and 95 ± 0.57% of the essential oil was successfully entrapped in the liposomes. The main constituents of the essential oil detected by GC-MS were; phenol, 1, 8 cineole, limonene, alcohol, pinene and terpinen. Results of particle size determination showed a wide range from 40.5 to 298 nm for the different formulations. No significant thixotropy was observed in the rheogram of the formulated liposomal gel. Conclusion: Liposomal gel formulation of the essential oil may lead to improved antifungal activity. | en |
| DOI | https://doi.org/10.17795/jjnpp-5261 | en |
| Keyword | Eucalyptus camaldulensis | en |
| Keyword | Essential Oil | en |
| Keyword | Liposomes | en |
| Keyword | Antifungal Activity | en |
| Publisher | Brieflands | en |
| Title | Preparation and Characterization of Liposomes Containing Essential Oil of Eucalyptus camaldulensis Leaf | en |
| Type | Research Article | en |
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