Ionic Liquid-assisted Synthesis of Celexocib Using Tris-(2-hydroxyethyl) Ammonium Acetate as an Efficient and Reusable Catalyst
| Author | Hamid Reza Ahfad-Hosseini | en |
| Author | Hasan Bagheri | en |
| Author | Salimeh Amidi | en |
| Issued Date | 2017-01-31 | en |
| Abstract | Celecoxib is classified as none traditional nonsteroidal anti-inflammatory drugs (NSAIDs). This compound has conventional properties of NSAIDs such as anti-inflammatory, analgesic, and antipyretic activities beside reduced risk of gastrointestinal side effect of traditional NSAIDs such as ibuprofen. This compound gets a second sale rank of NSAIDs market at 2016 in the world and sales more than 17000 Kg in Iran during the past 6 month. So, a simple, rapid and green method for synthesis of this compound is important. In the present study, a novel green method was suggested for the synthesis of celecoxib using the ionic liquid. | en |
| DOI | https://doi.org/10.22037/ijpr.2017.2016 | en |
| Keyword | Celecoxib | en |
| Keyword | Anti-inflammatory agent | en |
| Keyword | Ionic liquid | en |
| Keyword | Trifluoroacetone | en |
| Keyword | 4-methylbenzoylchloride | en |
| Keyword | 4-hydrazinobenzenesulfonamide hydrochloride | en |
| Publisher | Brieflands | en |
| Title | Ionic Liquid-assisted Synthesis of Celexocib Using Tris-(2-hydroxyethyl) Ammonium Acetate as an Efficient and Reusable Catalyst | en |
| Type | Original Article | en |
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